An emotion regulation strategy known as cognitive reassessment helped reduce the commonly increased and habitual focus on drug-related cues and contexts in cocaine-addicted individuals, a study by Mount Sinai researchers has found . in a paper published in PNAS, the team suggested that this form of habit disruption, mediated by the brain’s prefrontal cortex (PFC), may play an important role in reducing drug-seeking behavior and relapses that are hallmark, and long-standing. There are challenges. Addiction.
Main author Muhammad A. Parwaz, Ph.D. Said, “Addiction remission often stems from an increased attention-bias toward drug-related cues, which can include sights, smells, interactions, anything that can help someone remember their previous drug use.” reminds me of.” Assistant Professor of Psychiatry and Neuroscience at the Icans School of Medicine in Mount Sinai, which studies brain-based and behavioral markers that can inform and track addiction treatment and its consequences. “Our study is the first to suggest that self-regulation of stimuli for drug-related cues through cognitive reassessment may disrupt the brain’s automatic attention-bias to these cues, potentially binding drug- May lead to deficits in seeking behavior, even out-of-the-labor, in individuals with substance use disorders.”
Cocaine is a potent central nervous system stimulant whose abuse poses serious health risks and side effects. Cocaine addiction is recognized as a treatment-resistant disorder that has reached epidemic proportions nationally and globally. In the United States alone, hundreds of thousands of people are treated in emergency rooms each year after severe (mostly cardiac) symptoms associated with cocaine use. Chronic use of substance abuse, including cocaine, predisposes the brain’s attentive systems to pay more attention to drug-related cues in the environment (also known as attention-bias), a risk for relapse. factor is considered.
In this study Mount Sinai researchers noted that the use of cognitive reappraisal may disrupt habitually increased attention allocation to drug-related cues in individuals with cocaine use disorder. Cognitive revaluation is an emotion regulation technique in which individuals are trained to self-regulate (thereby involving the prefrontal cortex) an emotional response to a encountered cue or context by reinterpreting its meaning. For example, rows of cocaine in a given image can be re-interpreted as a movie prop with sugar powder only to be displayed as cocaine. While cognitive assessment has been employed by prior studies to reduce participants’ response to drug cues, Mount Sinai’s research for its effect on spontaneous (uncontrolled and habitual) attention-bias in individuals with cocaine addiction. Is the first to use this emotion regulation technique. -Related sign.
“Attention-bias modification has been a fundamental, though elusive, goal of repetition reduction for years,” said Dr. Parvaz, director of the Motivational and Affective Psychopathology Laboratory at Mount Sinai. “We found that cognitive reappraisal, a function of prefrontal control, reduces innate attention-bias to drug-related cues in people with cocaine addiction. Put another way, PFC-mediated cognitive control (a function of the assessment process) ) Has resulted in an increase in automatic (difficult to control) attentive procedures in drug-addicted humans.
“Through our work and based on prefrontal cortical mediation benefits of cognitive reassessment, we have provided a promising framework for self-regulation of automatic bottom-up and very difficult to counteract drug cue-reactivity, because Can potentially be generalized to reduce drug use. Applied to drug addiction other than lab and cocaine, “Rita Z. Goldstein, PhD, professor of psychiatry and neurology, and Neuropsychimaging of Addiction and Related Head of Conditions Research Program, Mount Sinai and senior author said. paper. “With further research, we think these results may contribute to the development of easily deployable cognitive behavioral and personalized intervention strategies, which can be used by drug addicts. Contributing to the development of empirically validated neuroscience-based interventions has been an important goal in our laboratory.”
A brain signature that predicts vulnerability to addiction
Muhammad A. Parvaz al al., “Attention bias modification in drug addiction: increasing control of later habits,” PNAS (2021). www.pnas.org/cgi/doi/10.1073/pnas.2012941118
Mount Sinai Hospital
Emotional regulation techniques may be effective in inhibiting compulsive cocaine addiction (2021, May 31)
1 June 2021. retrieve
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