May 9, 2021


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How our immune system helps us cope with antibiotics

Although both our immune system and our antibiotics have great potential to fight life-threatening infections, Antibiotic resistance It makes it difficult to cure common infections that were once easily cured. Antibiotic resistance occurs when bacteria evolve and survive the treatments intended to destroy them – then replicate or transmit this resistance to other bacteria.

Much research is currently being done to find ways to prevent the spread of antibiotics. But there are still many unanswered questions. One such question is how to deal with opposition in real time. Knowing what happens in the body during an infection can help us develop better treatments for antibiotics.

In us A recently published study, We have examined the amount of bacteria in the lungs of a highly contagious pneumonia patient with a typical bacterial type lung. Pseudomonas Aruginosa. By identifying the patient’s infection, we are able to see in real time how rapid the changes of both antibiotics are needed alongside the immune system.

We have used a number of techniques and experiments to measure the growth of bacteria and any changes in antibiotic resistance during the course of the disease. We combined these experiments with genome sequencing methods to detect changes in the bacterial genetic code. It tells us how bacteria change, and how it changes resistance to antibiotics.

They also measured the number of immune system molecules known to fight in the lungs Pseudomonas Aruginosa. Samples from the lungs were analyzed every few days – allowing us to capture the changes in high quality. The role of the immune system in suppressing the development of antibiotic-resistant bacteria is described in an unprecedented detail.

We found that the bacteria in the lungs were very resistant to one of the antibiotics used to kill them. These bacteria alter their ability to change and alter the cell wall (the outer layer around the cell). Some bacteria have even been found in the cell wall, which is used to kill antibiotics. Others have found that the structure of this layer has changed.

How our immune system and antibiotics can work with infection.

When he changes the starting point, he increases his resistance to antibiotics, but he makes the bacteria fit. As a result, it has grown slowly. Following the completion of antibiotic treatment, these highly resistant bacteria quickly disappeared from the population, becoming more suitable and replaced by their rapidly growing relatives.

But bacteria that only improve the structure of their cell walls increase their resistance to antibiotics – at no cost to their survival. In fact, they have grown rapidly. If these bacteria are passed on to others, they can cause serious infections that can be treated with antibiotics. These bacteria remain in the lungs – even after being replaced by less efficient relatives.

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We found that before the person was treated with antibiotics, the number of bacteria that caused the infection had already decreased. This shows that the immune system is working. This makes antibiotics more effective because they work better when targeting a small bacterial community.

However, the bacterial infection reappeared 11 days after the last exposure – and with antibiotic-resistant variants. For the first time, the immune system has worked with antibiotics. No new pesticides have been given at this time, and our study has shown that the immune system is able to fight off the infection on its own.

Significantly, this natural defense was able to kill the number of antibiotics that developed following the first antibiotic treatment.

We cannot be 100% sure that the bacteria are not transmitted to other people, but the bacteria are less likely to be transmitted when they are at a high level in the lungs. Such infections can be transmitted by coughing and expelling bacteria from the lungs.

Our findings suggest that immunosuppression inhibits resistance during the course of the disease and limits the transmission of resistant strains among patients. Using this link in the future can help us develop new treatments for harmful bacteria – and help us better prevent the spread of antibiotic-resistant bacteria.